Teneligliptin 20 mg + Metformin 1000 mg



Teneligliptin + Metformin are an anti-diabetic combination drug indicated for Type 2 diabetes mellitus. The medicine controls glycaemic control in diabetic patients, especially in those cases that do not react well to Metformin alone. Type 2 diabetes mellitus is a chronic disease in which the body does not produce enough insulin (a hormone that metabolizes sugar) consequently, leading to a spiked glucose level in the body. Teneligliptin + Metformin tablets are a combination medicine that synergistically helps in balancing blood glucose levels. Metformin belongs to the category of medications known as ‘biguanides’, and it works by reducing liver glucose production and intestinal glucose uptake. Teneligliptin works by inhibiting the action of the dipeptidyl Peptidase 4 enzyme, which in turn shoots up the insulin levels in the body and reduces the glucagon levels.

The medicine should be taken as per the dosage prescribed by your doctor. Do not crush, chew or break the tablet. Swallow it whole with water in the dosage and duration prescribed by the doctor. The tablets shall be stored in a cool and dry place away from direct sunlight. The regular use of Teneligliptin + Metformin tablets can induce a range of side effects. Some of the most common side effects are diarrhea, nausea, vomiting, hypoglycemia (low blood glucose level), decreased appetite, abdominal bloating, flatulence, constipation, etc. Before taking the tablets inform your doctor if you have a history of abdominal operation or intestinal obstruction, hypokalaemia (low blood potassium levels), type I diabetes mellitus (insulin-dependent diabetes), severe traumatic conditions, etc.

Uses of Teneligliptin + Metformin Tablets

  • Treats Type II diabetes mellitus

Side Effects of Teneligliptin + Metformin Tablets

Teneligliptin + Metformin tablets are potent drugs capable of inducing a wide range of mild to moderate side effects. The side effects resolve gradually and do not require any medical consultation. If in case the side effects persist or get severe, immediately seek medical consultation. Some commonly seen side effects are given below:

  • Respiratory infection
  • Weight gain
  • Sweating
  • Palpitations
  • Numbness
  • Vision problems
  • Nausea (feeling sick)
  • Vomiting (falling sick)
  • Diarrhea
  • Headache
  • Stomach ache

Drug Interactions

Some drugs when combined or taken with other drugs can cancel each other’s efficacy or may lead to unpleasant effects. The same is true for certain food items and beverages.

Interaction with Medicines:

  • Rifampicin (a medicine used to treat tuberculosis)
  • Ranolazine (a medicine used to treat chest pain)
  • Trimethoprim (a medicine used to treat bacterial infection)
  • Medicines used to treat cancer (Ex. vandetanib, crizotinib, and Olaparib)
  • Isavuconazole (a medicine used to treat fungal infections)
  • Salicylic acid (a medicine used to treat skin problems like acne)
  • Medicines used to treat depression (Ex. phenelzine, selegiline)
  • Adrenaline (a medicine used to treat shock caused by allergic reactions or collapse)
  • Thyroid hormones (used to treat thyroid deficiency) Ex. levothyroxine, liothyronine
  • Medicines used to treat irregular heartbeats (Ex. quinidine, procainamide, amiodarone, sotalol, etc.)
  • Other medicines used to treat diabetes (Ex. glimepiride, glyburide, gliclazide, rosiglitazone, pioglitazone)
  • Iodine contrast medium (used during X-rays)
  • Medicines used to treat asthma (Ex. salbutamol or terbutaline)
  • Corticosteroids (used to treat pain and inflammation) Ex. hydrocortisone, prednisolone
  • Diuretics (used to reduce edema and to treat hypertension) Ex. furosemide, hydrochlorothiazide
  • Medicines used to treat pain and inflammation (such as ibuprofen and celecoxib)
  • Medicines used to treat high blood pressure (such as atenolol, propranolol, captopril, enalapril, ramipril, lisinopril, losartan, valsartan, olmesartan, telmisartan)
  • Cimetidine (a medicine used to treat stomach ulcers)
  • Dolutegravir (a medicine used to treat HIV infection)
  • Verapamil (a medicine used to treat heart problems)

Interaction with Disease:

  • Heart diseases (congestive heart failure and myocardial infarction)
  • Vitamin B12 deficiency
  • Alcoholism
  • Type I diabetes
  • Bladder cancer
  • Oedema (fluid retention)
  • Liver disease
  • Premenopausal anovulation
  • Obesity (weight gain)
  • Anaemia

Precautions and Warnings

1. Do not consume alcohol along with Teneligliptin + Metformin as it increases the risk of getting a deadly disease called lactic acidosis.

2. Pregnant women should avoid taking Teneligliptin + Metformin as it is known to affect the fetus.

3. A breastfeeding mother should not consume Teneligliptin + Metformin tablets as the drug can seep into the breast milk and affect the newborn.

4. Teneligliptin + Metformin cause vision problems. Hence, avoid driving when under the medicine’s influence.

5. Patients with liver and kidney problems should not take Teneligliptin + Metformin as it can worsen their condition.

Frequently Asked Questions (FAQs)

  1. How does Teneligliptin + Metformin work?

TENELIGLIPTIN + METFORMIN is a combination of two antidiabetic medicines, Metformin, and Teneligliptin. It works by increasing insulin production, helping to restore your body’s appropriate response to insulin, especially muscle and fatty tissues, thereby lowering your elevated blood sugar levels.

  1. Can the use of Metformin+Teneligliptin lead to Vitamin B12 deficiency?

Yes, the use of Metformin+Teneligliptin can cause Vitamin B12 deficiency on long-term use. It interferes with the absorption of Vitamin B12 in the stomach.



Teneligliptin 20 mg + Metformin 1000 mg

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